Beyond their interactions with T‐cells and fibroblasts, SPP1+ TAMs expressing angiogenic, matrix remodelling, and immunosuppressive markers like Nlrp3, Tnf, Vegfa, and Arg1, also engage in cross‐talk with enteric glial cells via IL1R/IL6 signalling, further influencing tumour behaviour [57]. Here, SPP1 is linked to neoplasm.