Interestingly, some reports suggest that SPP1+ macrophages display a foamy‐like morphology with enhanced lipid metabolism and phagocytic activity in atherosclerosis settings [63], raising the question of whether PPARγ‐driven metabolic adaptations contribute to their foamy‐like appearance, enhanced lipid metabolism, phagocytic activity, as well as tumour‐supporting functions in cancer contexts. This evidence concerns the gene PPARG and neoplasm.