Further evidence of the tumour‐promoting role of SPP1+ TAMs comes from a murine lung adenocarcinoma model, where a population of TREM2+ macrophages, also expressing the SPP1+ gene signature (TREM2, GPNMB, SPP1, CTSB, RNASE1, GPR183), was identified [73]. This evidence concerns the gene SPP1 and lung adenocarcinoma.