SPP1 and cancer: Interestingly, some reports suggest that SPP1+ macrophages display a foamy‐like morphology with enhanced lipid metabolism and phagocytic activity in atherosclerosis settings [63], raising the question of whether PPARγ‐driven metabolic adaptations contribute to their foamy‐like appearance, enhanced lipid metabolism, phagocytic activity, as well as tumour‐supporting functions in cancer contexts.