They are used to treat type 2 diabetes through the stimulation of insulin secretion.55 GLP-1RAs are also effective in weight loss by delaying gastric emptying, and by decreasing appetite and craving through a complex signaling to the brain.56 Because of the dual effects of GLP-1RAs, they have been proposed to act as a CPA for CRC. Here, INS is linked to type 2 diabetes mellitus.