It has been reported that, during the early stage of T. gondii type I and III infection, mouse macrophages tend to M2 phenotype through the STAT3/STAT6 pathways by rhoptry protein 16, while type II infected macrophages tend to M1 phenotype via dense granule protein 15 phosphorylated NF-κB [21]. This evidence concerns the gene NFKB1 and infection.