ARG1 and infection: Consistent with our previous results, the number and size of ME49Δcdpk3 strain plaques were larger than that of the ME49wt strain, and deficiency of Arginase-1 significantly decreased in the number and size of plaques formed caused by ME49Δcdpk3 strain infection, indicating that the deficiency of Arginase-1 results in resistance to the increase of plaques formation by ME49Δcdpk3 (Fig. 4D).