Utilizing data from The Cancer Genome Atlas Liver Hepatocellular Carcinoma project (TCGA-LIHC), we found this elevated HHLA2 mRNA expression (n = 371 samples with grade information) strongly correlated with advanced tumor grade (Supplemental Fig. 1B) and was associated with reduced overall survival (OS) (n = 371 samples with survival information, Supplemental Fig. 1C). This evidence concerns the gene HHLA2 and neoplasm.