In the KILR tumor cytotoxicity assays applied to SKBR3, NCI-N87, and Colo-205 tumor cells, bispecific antibody TB725-007 combining DKK1 CRD1 and CRD2 binders increased the cytotoxicity effect compared to that of DKK1 CRD2 binder SC52-002 alone (Fig. 5E). The gene discussed is DKK1; the disease is neoplasm.