Along these lines we show that BCP-ALLs of Pax5± mice display off-target SVs like Kmt2c, Runx1 and Phf6. These genes share function in chromatin remodeling, DNA repair and have been found as early events predisposing to infant, T- and myeloid leukemia [49–52]. The gene discussed is RUNX1; the disease is myeloid leukemia.