Unexpectedly, there were very few differentially expressed genes between mtUBA1 and wtUBA1 monocytes; no differences were observed in both the sepsis-associated monocyte signature gene and HLA class II gene module scores, suggesting a global dysfunctional gene signature of VEXAS monocytes, irrespective of the UBA1 genotype (Supplementary Fig. 3e, f; Supplementary Data 3). This evidence concerns the gene UBA1 and Sepsis.