REN and myocardial infarction: The progression of VHD after AMI may be explained by the post-AMI valvular remodeling caused by the neurohumoral activation, including the renin-angiotensin-aldosterone system, activation of fibrotic pathways, and increased collagen production and valve thickness13,16,17 Therefore, it is important to assess the progression of VHD severity and the need for valve intervention even shortly after MI and to continue in long-term follow-up.