ASH1L and metastatic malignant neoplasm: Specifically, 46% and 35% of the downregulated DEGs (FDR ≤0.05; FC ≥1.5) showed decreased H3K4me3 and H3K36me3 signals, respectively (p values of overlap <1e-300, by Fisher’s exact test) (Fig. 2f), suggesting that these genes (n = 1180) are the most likely direct targets of ASH1L in metastatic cancer cells (Supplementary Data 4).