HIF1A and cancer: Then, we analyzed a published HIF-1α ChIP-sequencing dataset in PC-3 cells (GSE106305)39 and found that 83.2% (982 in 1180) of ASH1L direct target genes (Supplementary Data 4) were bound with HIF-1α protein in their promoter regions, including those are associated with cancer invasiveness and metastasis (Supplementary Fig. 5a and Supplementary Data 5).