It is worth noting that ASH1L also co-localized with HIF-1α on the promoter regions of genes in leukemia cells (Supplementary Fig. 5k, l and Supplementary Data 5); however, only 32.5% (1132 in 3482) of ASH1L target genes were shared with HIF-1α, which are distinct from those in metastatic PCa (Supplementary Fig. 5k, l and Supplementary Data 5). This evidence concerns the gene ASH1L and posterior cortical atrophy.