We found that myeloid components in human metastatic tumors were mainly composed of monocytes and TAMs, and all three TAM clusters highly expressed lipid-associated TAM markers (APOE, C1QA, and TREM2) and exhibited a pro-tumoral phenotype featured by CD206 (MRC1) expression (Fig. 7j and Supplementary Fig. 10b, c). Here, APOE is linked to metastatic neoplasm.