The AFR and SAS groups in Genomics England were both significantly enriched for BRCA1 (AFR, OR 6.21 [95% CI (2.72, 14.1), logistic regression p = 1.4 × 10−5]; SAS, OR 4.27 [95% CI (1.6, 11.4), logistic regression p = 0.0038]) mutations as well as those commonly associated with mechanisms of DNA damage: nucleotide excision repair; mismatch repair; Fanconi anaemia germline mutations (Supplementary Data 8). Here, BRCA1 is linked to Fanconi anemia.