PTPRC and childhood gender nonconformity: To determine the mode of T cells activation by IFN-I during cGN, we performed scRNA-seq analyses on CD45+ leukocytes from the kidney, spleen, and blood, as well as CD45- kidney cells, isolated from nephritic mice 10 days after cGN induction (Fig. 6a–d and Supplementary Fig. 9a–d).