EIF2AK3 and diabetic cardiomyopathy: Similarly, other studies have reported that TMAO induces the PERK-EIF2α-ER stress signaling axis in ex vivo slices and db/db mice [127] and that administration of a Chinese herb ameliorated diabetic cardiomyopathy in mice by reducing serum TMAO levels and suppressing the TMAO/PERK/FoxO1 signaling pathway [128].