For instance, in bladder and other cancers, CCNE1 amplification has been linked to chemoresistance due to alterations in DNA damage repair pathways, potentially leading to a homologous recombination-proficient phenotype.22 Notably, CCNE1 amplification has been associated with synthetic lethality when combined with PKMYT1 inhibition. This evidence concerns the gene PKMYT1 and cancer.