PKMYT1 and cancer: It is a negative regulator of mitosis entry, mainly phosphorylating CDK1 on threonine 14.43 The data showed that PKMYT1 plays an essential tumorigenic role in colorectal tumors, hepatocellular carcinoma, and OS and may be an efficient therapeutic target for cancer treatment.18,44 However, as a phosphorylating kinase, it remains unknown whether PKMYT1 regulates DDP sensitivity in OS through phosphorylation modification.