EPCAM and cancer: While this aligns well with results from gene expression profiling across multiple cancer entities [11–14], it constitutes a noteworthy difference to cell lines models of prototypical EMT and mouse models of pancreatic ductal adenocarcinoma, skin squamous cell carcinoma, and mammary carcinoma where exit from fully epithelial states is accompanied by immediate downregulation for example of Epcam and Cdh1 expression [3, 5].