Taken together, our data show that WLWH with BC in SSA undergoing HAART showed (i) an activated IFN-γ signaling in the TME, (ii) an upregulation of the ICP molecule CD276 and (iii) a more pronounced T cell exhaustion in particular in WLWH - IS and (iv) an aberrant T cell composition and distribution in WLWH that was independent from peripheral blood CD4+ T cell numbers. The gene discussed is CD4; the disease is breast cancer.