This revealed 24 significantly upregulated gene sets in BC specimens of WLWH including the inflammatory response, TNF- α signaling via NF-kB, TGF-β signaling, IFN-α and IFN-γ response, while only the myc target V1 gene set was downregulated (Fig. 7L and Supplementary Fig. 8). This evidence concerns the gene TNF and breast cancer.