In order to investigate the impact of the HIV status on the expression of these genes in the BC TME, we next analyzed the interrelationship of HIV status on the expression of CD4, CD8, and CD276 (Fig. 4A–F) demonstrating a lower CD4 expression in WLWH - VS, but a trend of higher CD8 expression in WLWH - IS. The gene discussed is CD8A; the disease is breast cancer.