To further clarify the role of endogenous Metrnl in liver fibrosis, we utilized global Metrnl knockout mice (Metrnl−/−) and validated the efficiency of the Metrnl gene knockout using qPCR analysis of liver tissue from wild-type (WT) and Metrnl−/− mice (Supplementary Fig. 2A, B). The gene discussed is METRNL; the disease is Hepatic fibrosis.