To experimentally test this hypothesis, we analyzed saturationbinding to SST2 on intact MPC cells for [64Cu]­Cu-NODAGA-cLAB2-TATE (as a modelheterobivalent radioligand) in the presence of different albumin concentrations.Furthermore, we propose a dedicated three-compartment model for thequantitative description of the principal effects of albumin bindingof radioligands in the blood circulation on the time course of excretionand tumor uptake when considering different tissue uptake rates ofthe free and albumin-bound radioligand, respectively. Here, ALB is linked to neoplasm.