ALB and neoplasm: Generally, binding to albuminshould not increase the integral tumor uptake per se as the total area under the concentration–time curve (AUC)of the free (unbound) radioligand fraction, which initially shouldbe assumed to be the sole target-reactive species, is not alteredby albumin binding.−,  Accordingly, the common statement that the increasein blood circulation time of the radioligand due to binding to albuminleads to an increased tumor uptake is erroneous.