Moreover,the albumin-bound radioligand can be retained in the tumor tissueby additional uptake mechanisms that do not rely on the actual moleculartarget and its vector molecule but rather on albumin itself (i.e.,enhanced permeability and retention effect, EPR). The contributions of the aforementioned mechanisms thatmight cause an increased integral tumor uptake certainly depend onthe particular target, the albumin-binding moiety, and tumor entity,and a better mechanistic understanding might support the clinicaltranslation of albumin-binding radioligands. The gene discussed is ALB; the disease is neoplasm.