In line with this, nanoparticle functionalization has shown promising effects in preclinical animal models of AD in which delivery of anti-amyloid heavy chain antibody fragments (VHH) is increased by intravenous injection of glutathione- and PEG-coated (addition of polyethylene glycol to prolong blood circulation time) liposomes compared to a non-liposomal VHH [92]. Here, SLC3A2 is linked to Alzheimer disease.