Other potential mediators of impaired leptin action in obesity include obesity-induced inflammation, cellular endoplasmic reticulum stress, and LepRb deacetylation (Zhang et al. 2008; Ozcan et al. 2009; Wisse and Schwartz 2009; Thaler et al. 2012; Guan et al. 2024). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.