KRAS and neoplasm: GEA of differentially expressed genes (DEGs) between the tumor core and invasive edge (Table S8) reveals that, while cell cycle and WNT signaling pathways are enriched among upregulated genes in the tumor core, the invasive edge is enriched with EMT, hypoxia, IFN-γ response, NF-κB, angiogenesis, and Kirsten rat sarcoma virus (KRAS) signaling (Figures 4C, S10A, and S10B), further indicating that MAPK signaling may drive transitions into (i)REC states at invasive fronts.