Furthermore, APOE is highly expressed in SPP1+ and IL1B+ TAMs and has been shown to induce expression of immunosuppressive factors such as CXCL1 and CXCL5,71, whereas ANXA1 has been implicated in promoting immune suppression72 and resistance to chemotherapy in CRC.73 This evidence concerns the gene CXCL5 and colorectal carcinoma.