The overall beneficialeffect on T2DM is complemented by the production of adiponectin, whichalso increases glucose uptake in muscle cells. Today, partial PPARγ agonists that retain glucose-loweringbenefits are considered as promising strategy to reduce the risk ofadverse effects. Natural products fromtraditionally used medicinal plants have always been a promising poolof structures for drug discovery, and the field of PPARγ agonistsand hypoglycemics is no exception. This evidence concerns the gene PPARG and type 2 diabetes mellitus.