However, three DM-INI participants experienced worsening of their diabetes control, which is unaffected by INI, as indicated by consistently increased levels of plasma insulin (10.60 ± 8.57 uIU/ml), HOMA-IR (3.23 ± 3.05), fasting glucose (11.67 ± 2.08 mg/dl), NW (-9.81 ± 3.96 m/s), and DTW (-10.03 ± 7.79 m/s). This evidence concerns the gene INS and diabetes mellitus.