Upregulation of the pro-inflammatory cytokines TNF-α, IL-1, and IL-6 stimulates the production of positive acute-phase proteins such as c-reactive protein (CRP) [4], the concentration of which increases reliably in inflammation in dogs, but is nonspecific and unable to reliably distinguish between sepsis and non-septic SIRS, nor to provide an accurate prognosis [5,6]. Here, CRP is linked to Sepsis.