Overall, the cellular positivity ranged from 5% to 95% with combined 2 + & 3 + intensities in 68% (17/25), 32% (8/25), and 84% (21/25) for ER, PR, and AR respectively (S1 Table), indicative of the higher rate and stronger expression of AR in HGSCA diagnostic cancer category. Here, ESR1 is linked to cancer.