In Chinese retrospective studies, a sharp-falling of AFP was significant for predicting OS after hepatectomy (a high preoperative AFP value > 200 ng/mL, declining rapidly below 25 ng/mL in the second or third follow-up within four months) and TACE (first AFP measuring ≥ 316 ng/mL, declining toward at least < 100 ng/mL within 4 months) in intermediate staged HCC [13,14]. Here, AFP is linked to hepatocellular carcinoma.