HIF1A and lung carcinoma: In the context of HIF-1 down-regulation by Endostar, which was shown in this study, to demonstrate the role of HIF-1 on the MHC class I α-heavy chain and β2 m light chain in A549 and NCI-H1299 lung cancer cells, the over-expressing HIF-1 gene was transfected into A549 and NCI-H1299 cells resulting in decrease of relative levels of MHC class I α-heavy chain and β2 m light chain.