COL18A1 and non-small cell lung carcinoma: Endostar was developed as a specific drug permitted by the State Food and Drug Administration in China in 2005 for its use in NSCLC therapy.25,26 Endostatin is a natural protein, first isolated and extracted from mouse tumors by Judah Folkman, with a wide antitumor spectrum and strong antiangiogenic capacity.27,28 Angiogenesis is a physiological process of forming new blood vessels from existing blood vessels and circulating endothelial precursors.