Our earlier study in human HD brains Berg et al., 2024 found a high degree of colocalization of mHTT/Ub or Ub/p62 colocalized signals in IBs, suggesting a relationship between mHTT and the autophagy machinery since p62 and Ub are adaptor proteins mediating autophagic cargo sequestration. This evidence concerns the gene SQSTM1 and Huntington disease.