Of particular relevance to our present study are those involving autophagy induction with mTOR-dependent or -independent autophagy-enhancing approaches in HD mouse models [e.g. Trehalose Tanaka et al., 2004; Rapamycin analog Temsirolimus (CCI-779) Ravikumar et al., 2004; Rilmenidine Rose et al., 2010; Rhes manipulations Baiamonte et al., 2013; Lee et al., 2015]. The gene discussed is MTOR; the disease is Huntington disease.