Crossing TRGL mice with a model of a neurodegenerative disease, the Q175 mouse model of HD, has enabled us to assess disease-related autophagy alterations in the Q175 and TRGL/Q175 models and their response to a pharmacological inhibition of mTOR, (mTORi) INK-128 (hereafter INK). Here, MTOR is linked to Huntington disease.