TBXT and head and neck squamous cell carcinoma: Therefore, the T-cell receptor signaling pathway (hsa04660) was further analyzed, revealing that neither PDCD1 (PD-1) nor CTLA4, the ICIs target ligands, were upregulated in HNSCC, as also confirmed by ST (Fig. 4d, Online Resource 7) and SIN (data not shown) compared with NOM.