In a model of EBV-infected B-cell lymphoma using humanized mice (immunodeficient NOG mice reconstituted with human hematopoietic cells), sPLA2-X is expressed in a population of lipid-laden macrophages and hydrolyzes phospholipids in lymphoma-derived EVs to produce lysophospholipids such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), which are further converted to LPA by EV-associated autotaxin (ATX), an extracellular lysophospholipase D (49, 51). The gene discussed is PLA2G10; the disease is B-cell non-Hodgkin lymphoma.