In WAT, sPLA2-IID is expressed in M2-like macrophages and inversely correlated with obesity, and global and macrophage-specific sPLA2-IID deficiency exacerbates diet-induced obesity and attenuates cold-induced adipocyte browning and thermogenesis (39). The gene discussed is PLA2G2D; the disease is obesity due to melanocortin 4 receptor deficiency.