These findings underscore the role of the sPLA2-IID–EV–ω3 PUFA axis to maintain metabolic health (39) and may be relevant to the finding that a G80S polymorphism of human sPLA2-IID is associated with body weight changes in patients with chronic obstructive pulmonary disease (41). The gene discussed is PLA2G2D; the disease is chronic obstructive pulmonary disease.