IGF2BP3 is a potent post‐transcriptional oncogene that stabilizes numerous target gene RNAs, promoting tumor growth, metastasis, and drug resistance.[35] Previous studies have reported that IGF2BP3 promotes GPX4 expression to inhibit ferroptosis in glioma and lung adenocarcinoma.[20] Whether this regulatory relationship plays a role in ICC and tumor chemotherapy resistance remains unknown. This evidence concerns the gene GPX4 and intrahepatic cholangiocarcinoma.