Third, given that ICC has entered the era of immunotherapy [39] and ferroptosis plays a multifaceted role in antitumor immunity,[40] it remains unclear whether the PAX8‐AS1/GPX4 axis influences immune interactions or whether JKE‐1674‐induced ferroptosis can stimulate an antitumor immune response to overcome chemoresistance. The gene discussed is PAX8; the disease is intrahepatic cholangiocarcinoma.