MiR‐233 expressed in neutrophils silences NLRP3 in pro‐inflammatory macrophages and triggers the activation of restorative macrophage phenotype to release IL‐10, which inhibits HSCs activation and collagen deposition in early liver fibrosis.[123] Moreover, neutrophils also express pro‐reparative proteases, such as MMPs. The gene discussed is IL10; the disease is Hepatic fibrosis.