PTEN and Hepatic fibrosis: In arsenite‐induced hepatic fibrosis, miR‐21 accelerates the glycolysis of CD4+ T cells to promote CD4+ T‐cell polarization toward pro‐fibrotic Th2 cells through the PTEN/PI3K/AKT pathway in mice.[259] The similarity in metabolic changes across different organ types points to the key pathway, glycolysis, regulating the homeostasis of the ECM and fibrosis.