In SSc, CD8+ T cells and CCR7− CD4+ memory T cells can produce IL‐13 to promote the transition of fibroblasts to myofibroblasts and ECM production.[82] Moreover, the increased myocardial infiltration of T lymphocytes and macrophages is an important pathological feature of immune checkpoint inhibitor (ICI) myocarditis. Here, CD8A is linked to myocarditis.