Moreover, as a DCs‐derived EGFR ligand, epiregulin activates fibroblasts to contribute to ECM overproduction in skin and lung fibrosis.[88] Activated CD1c+ DC in the presence of the proximal epithelial cells undergoing ferroptosis shows NLRP3 inflammasome signaling activation, which is responsible for the release of pro‐inflammatory cytokines including IL‐1β and IL‐18 and is pivotal for tubulointerstitial fibrosis and inflammation.[89] Thus, the immaturation and immunosuppression of DCs could be considered as anti‐fibrotic approaches. This evidence concerns the gene IL1B and pulmonary fibrosis.