Anti‐fibrotic macrophages are found in nonalcoholic steatohepatitis (NASH) mice, including Trem2+ macrophages and Vsig4+ macrophages.[32, 33] The restorative CD11BhiF4/80intLy6Clo macrophage subset found in the liver can secrete matrix metalloproteinases (MMPs) and activate the apoptotic pathway for fibrosis resolution.[34, 35] Promoting the phenotypic switch from general pro‐fibrotic Ly6Chigh macrophage to restorative Ly6Clow macrophage may be considered as a new fibrosis treatment. The gene discussed is VSIG4; the disease is metabolic dysfunction-associated steatohepatitis.