During NAFLD progression to NASH, biliary‐secreted IGF‐1 enhances mast cell infiltration and activation, leading to severe biliary and liver damage, and microvesicular steatosis particularly in portal areas hepatocytes via miR‐144‐3p/ALDH1A3 signaling.[142] Cell‐surface receptor KIT and its ligand, stem cell factor (SCF), have diversiform effects on mast cell development and function. The gene discussed is KITLG; the disease is metabolic dysfunction-associated steatohepatitis.