In addition, neutrophils could release profibrotic cytokines, including IL‐17,[103] IL‐6, and VEGF.[82] Neutrophils‐produced ROS induces the activation and proliferation of hepatic stellate cells (HSCs); meanwhile, activated HSCs could secrete IL‐15 and GM‐CSF to inhibit the neutrophils apoptosis in liver fibrosis (Figure 3A).[104]. The gene discussed is IL17A; the disease is Hepatic fibrosis.