Exposure of macrophages to a high‐salt diet induces trained immunity that enhances the inflammatory response in the kidney upon subsequent exposure to LPS.[247] Targeting the mTOR signaling pathway, which is critical for the development of trained immunity induced by a high‐salt diet, with the drug rapamycin, may offer a potential avenue for mitigating fibrosis associated with chronic kidney disease. This evidence concerns the gene MTOR and chronic kidney disease.