Although this could be linked to FAO due to its role in acetyl‐CoA production, in ccRCC, FAO is generally considered to be repressed through down‐regulation of CPT1A expression.[10] We have knocked out ATGL, one of the key enzymes for lipolysis, and have not observed its impact to histone acetylation. The gene discussed is PNPLA2; the disease is nonpapillary renal cell carcinoma.