SETD2 and nonpapillary renal cell carcinoma: Epigenetic dysregulation is critical for ccRCC.[18] SET domain containing 2 (SETD2), one enzyme for H3K36me3, is frequently mutated, and its protein product is degraded by speckle‐type BTB/POZ protein (SPOP), one oncogenic E3 ligase, in ccRCC.[19, 20] HIF pathway is also one of the key processes for epigenetic reprogramming in ccRCC.