To verify the key TFs in ccRCC, we surveyed their relationships with patient survival rates according to the TCGA database, and found that the higher expression of iroquois homeobox 3 (IRX3), heat shock transcription factor 4 (HSF4), RUNX family transcription factor 1 (RUNX1), and CCAAT enhancer binding protein beta (CEBPB) is associated with low survival rates, suggesting they potentially play oncogenic roles in ccRCC (Figure S3E–H, Supporting Information). Here, HSF4 is linked to nonpapillary renal cell carcinoma.