IRX3 and nonpapillary renal cell carcinoma: To verify the key TFs in ccRCC, we surveyed their relationships with patient survival rates according to the TCGA database, and found that the higher expression of iroquois homeobox 3 (IRX3), heat shock transcription factor 4 (HSF4), RUNX family transcription factor 1 (RUNX1), and CCAAT enhancer binding protein beta (CEBPB) is associated with low survival rates, suggesting they potentially play oncogenic roles in ccRCC (Figure S3E–H, Supporting Information).