It has been reported to be involved in the sensing of dietary ω‐6 linoleic acid and the pathological progression of metabolic disorders, breast cancer, and hepatocellular carcinoma.[28] Here we have identified FABP5 as an oncogene in ccRCC, which promotes ccRCC cell proliferation, migration, colony formation, organoid, and tumor growth. This evidence concerns the gene FABP5 and Other metabolic disease.