The activation of HIFs drives the expression of several histone H3K9 demethylases, such as lysine demethylase 4A (KDM4A), lysine demethylase 4B (KDM4B) and lysine demethylase 3A (KDM3A), which remove the repressive methylation marks of H3K9 and promote gene transcription.[21] Meanwhile, HIFs interact with E1A binding protein p300 (EP300) to loosen chromatin structure and activate transcription.[22] It has been reported that epigenetic reprogramming is associated with FA metabolism;[23] however, the interplay between them in the ccRCC is not clear. The gene discussed is KDM4B; the disease is nonpapillary renal cell carcinoma.