Interesting, unlike the Xkr8 knockout phenotype, the TMEM16F KO tumors showed a slight reduction in tumor growth in Rag KO mice (which lack mature T and B lymphocytes), with modest effects in tumor volume (Fig 5.L.) and tumor weight (Fig 5.M.), possibly suggesting that tumor reduction due to Xkr8 KO is more dependent on the mature T and B cells, whereas, in the TMEM16F KO tumors, there is a combined effect of the immune system and other factors, such as angiogenesis and modulation of the extracellular matrix, driving the reduction in tumor progression. The gene discussed is ANO6; the disease is neoplasm.