INS and Hyperinsulinemia: Including these terms improved performance of the model (R2 = 40%, P = 4.2E-9 for the model), and we found that sex had a significant interaction effect with insulin clearance during euglycemic hyperinsulinemia (P = .043; lower coefficient in women) and a trend for an interaction effect with antilipolytic effect of insulin (P = .072; lower coefficient in women) and serum triglycerides (P = .092; lower coefficient in women) (Supplementary Table S2 [21]).