TRIM21 and atrioventricular block: (63) proposed three potential types of anti-Ro/SSA antibody-associated AVB in adults (1): acquired type, typically caused by antibody-mediated immune interference and reversible with immunosuppressive therapy (2); late progressive congenital type, associated with structural damage during the fetal period and impossible to reverse with immunotherapy; and (3) mixed type, which may originate from subclinical fetal injury and is compounded by immune-mediated secondary damage in adulthood.