Furthermore, the miR‐497‐5p‐mediated NLRP3/caspase‐1/GSDMD pathway and the resulting inflammatory endothelial dysfunction in ox‐LDL‐stimulated HUVECs was also significantly attenuated after UCP2 overexpression (Figures 7E–G; Figure S8D). The gene discussed is UCP2; the disease is endothelial dysfunction.