Analysis of 4T1 tumors revealed significant increases in anti-tumor M1 Macrophage, CD4+ T cell, CD8+ T cell, NK cell, and NKT cell populations, significant increases in CD8+ T cell and NK cell activation, and a significant decrease or trending decrease in pro-tumor polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) and regulatory T cell (Treg) populations respectively in MerTK overexpressing tumors compared to Vector control (Figure 2D, Supplementary Figure S2). The gene discussed is CD4; the disease is neoplasm.