Through molecular docking and verification of key targets in the GEPIA2 database, we found that Dio had a strong binding affinity for the core targets of EGFR and CASP3, and the expression of EGFR and CASP3 mRNA in GBM tissues was significantly higher than that in normal tissues, and high expression of CASP3 was associated with a significantly lower survival rate. Here, EGFR is linked to glioblastoma.