In this regard, our future research can focus on (1) elucidating Dio’s specific regulation of different EGFR phosphorylation sites, (2) comparing Dio’s effects in EGFR wild-type vs EGFRvIII mutant GBM models, and (3) deciphering the causal relationship between EGFR phosphorylation upregulation and downstream pro-apoptotic signaling. Here, EGFR is linked to glioblastoma.