SGCB and migraine disorder: Furthermore, binding of NO to soluble guanylate cyclase (sGC) activates the enzyme, leading to increased levels of cyclic guanosine monophosphate (cGMP), which in turn induces the opening of large conductance calcium-activated potassium (BKCa) and ATP-sensitive potassium (KATP) channels, both of which are involved in migraine attacks [48,49].