Chronic and recurrent postprandial hyperglycemia leads to the overproduction of reactive free radicals and the release of inflammatory cytokines such as interleukin-6 (IL-6), IL-18 and tumor necrosis factor-α (TNF-α), all of which are mediated through the nuclear factor-κB oxidative stress signaling pathway [33, 34]. Here, IL18 is linked to Hyperglycemia.