Compared with the patients in the lowest tertile of serum asprosin (<250.7 pg/mL), patients with asprosin between 250.7–314.0 pg/mL [OR (95% CI) is 1.774 (0.978-3.218), P < 0.05] and asprosin >314 pg/mL [OR (95% CI) is 8.406 (4.788-14.758), P < 0.05] have a higher risk of obesity. Here, FBN1 is linked to obesity due to melanocortin 4 receptor deficiency.