The results showed that FIB (OR = 1.52, 95% CI: 1.11-2.08), ALB (OR = 0.92, 95% CI: 0.87-0.97), AIP (OR = 3.96, 95% CI: 1.91-8.24), LDL-C (OR = 1.43, 95% CI: 1.11-1.84), BMI (OR = 1.08, 95% CI: 1.01-1.16), classification of DR (OR = 2.81, 95% CI: 1.32-5.96), gender (OR = 0.36, 95% CI: 0.22-0.60), and history of hypertension (OR = 2.73, 95% CI: 1.73-4.30) were independent risk factors for the DR combined with DKD group (P < 0.05), as shown in Table 3. The gene discussed is ALB; the disease is diabetic kidney disease.