In MPTP mice, electroacupuncture stimulation at GV16, LR3, and ST36 resulted in increased claudin-1 expression in the colon, decreased activation of NLRP3 inflammatory vesicles, improved intestinal barrier integrity, suppression of inflammatory cytokine activation in the colon, and attenuation of behavioral deficits, which exerted a protective effect against PD [85]. This evidence concerns the gene CLDN1 and Parkinson disease.