IL6 and Anxiety: Oh et al. [90] showed that acupuncture stimulation of the GB34 acupoint significantly increased the number and degranulation ratio of local MCs, released mediators such as histamine decarboxylase and tryptase-like enzymes, which improved motor symptoms and anxiety-like behaviors, restored dopaminergic neuron activity in the SN and striatum, and inhibited neuroinflammatory markers (IL-6, IL-1β, and TNF-α) and glial cell activation.