Recent studies revealed the potential anti-inflammatory role of PTGIR agonists in an acute colitis murine model.30 We first assessed the effect of the PTGIR agonist BPS on YAP in vivo in an acute colitis murine model in which the mice were given drinking water containing 3% DSS for 7 days and then treated with BPS beginning on the second day of induction via oral gavage once per day (Figure S2A). This evidence concerns the gene PTGIR and colitis.