A previous study reporting that ATF3 regulates GSN expression as an upstream factor in bladder cancer.[34] Further research showed that following PA stimulation in AML12 cells, ATF3 expression was upregulated, and similar increases in ATF3 expression were observed in liver tissues of MASH patients, as well as in the livers of mice fed with three different high‐fat diets. This evidence concerns the gene GSN and metabolic dysfunction-associated steatohepatitis.