Cardiac overexpressing caspase-3 in transgenic mice revealed enlarged infarct size and manifested susceptibility to die after I/R injury while knockdown decreased infarct size and improved heart function in an acute myocardial infarction rat model.5, 19 Therefore, caspase-3 is one of the important biomarkers involved in myocardial infarction. This evidence concerns the gene CASP3 and myocardial infarction.