In the amyloid cascade, the accumulation of amyloid beta (Aβ) peptide in the form of amyloid plaques (APs) in the brain is an early and necessary event in Alzheimer's disease (AD), leading to downstream events including tau pathology, synaptic loss, and neuronal death resulting in clinical symptoms of cognitive impairment and eventually dementia.1, 2. Here, MAPT is linked to Alzheimer disease.