In accordance, both cytosolic and mitochondrial forms of LbNOX rescued cellular NAD+/NADH ratios and viability, indicating that while NADH shuttling systems in AML cells are very active, increased activity of complex I of the electron transport chain cannot prevent a drop in the NAD+/NADH ratio when LDHA activity is reduced. This evidence concerns the gene LDHA and acute myeloid leukemia.