Using the genetically encoded metabolic sensor SoNar, which like Peredox reports the cytosolic NADH/NAD+ ratio, it was shown that cells with high cytosolic NADH/NAD+ ratios are highly glycolytic, enriched for LSCs, and reside in the hypoxic endosteal niche in an MLL-AF9-driven model of mouse AML [13]. The gene discussed is MLLT3; the disease is acute myeloid leukemia.