KMT2A and acute myeloid leukemia: Using the genetically encoded metabolic sensor SoNar, which like Peredox reports the cytosolic NADH/NAD+ ratio, it was shown that cells with high cytosolic NADH/NAD+ ratios are highly glycolytic, enriched for LSCs, and reside in the hypoxic endosteal niche in an MLL-AF9-driven model of mouse AML [13].