We found that MX1 and MX2 genes were only modified with H3K27me3 in B cells (memory B, naïve B), myeloid leukocytes and NK cells, but not in T cells (CD4αβT, CD4 helper T, CD8 T, gamma delta T), indicating their primary function in innate immunity (Additional file 2: Fig. S5B); while IFIT5 gene was only unmodified with H3K27me3 in myeloid leukocytes, and it has been found that overexpression of this gene may be related to myeloid leukemia [41] (Additional file 2: Fig. S5A). The gene discussed is CD8A; the disease is myeloid leukemia.