Previous studies from our lab and others have demonstrated that interactions between HER2 and the scaffolding molecules, Sodium-Hydrogen Exchanger Regulatory Factor 1 (NHERF1) and Ezrin, stabilize interactions between HER2 and Heat Shock Protein 90 (HSP90), MAL2 and the calcium pump, Plasma membrane Ca2+ ATPase (PMCA2), all of which contribute to the plasma membrane retention of HER2 within lipid raft- and actin-rich membrane domains that protrude from the surface of cancer cells [6–18]. This evidence concerns the gene ERBB2 and cancer.