Interestingly, we identified rare areas of apparently normal appearing epithelium adjacent to human DCIS lesions, in which HER2 remained co-localized with Na/K ATPase in the basolateral membrane, but Ezrin and NHERF1 expression spread from the apical membrane into the basolateral compartment. The gene discussed is NHERF1; the disease is ductal breast carcinoma in situ.